NPR is an independent risk factor for predicting all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2007–2020

Table 5 The relationship between neutrophil-associated inflammatory markers with the mortality of MASLD(N = 1894) and ALF(N = 290)

Characteristics (ln-transformed)	Model 1¹		Model 2²		Model 3³
Characteristics (ln-transformed)	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
MASLD
NPR	3.10(2.16,4.45)	< 0.001	2.19(1.46,3.27)	< 0.001	1.98(1.32,2.96)	< 0.001
NHR	0.89(0.60,1.33)	0.573	1.06(0.73,1.55)	0.760	0.96(0.65,1.41)	0.829
SII	1.17(0.79,1.74)	0.441	1.14(0.77,1.71)	0.508	1.14(0.77,1.69)	0.527
SIRI	2.71(2.06,3.56)	< 0.001	1.51(1.04,2.19)	0.029	1.47(1.00,2.17)	0.052
ALF
NPR	2.06(0.71,5.95)	0.181	1.64(0.54,4.99)	0.381	1.21(0.38,3.84)	0.748
NHR	0.85(0.40,1.79)	0.666	0.87(0.44,1.74)	0.703	1.15(0.46,2.89)	0.765
SII	0.85(0.51,1.40)	0.516	0.96(0.58,1.58)	0.865	1.60(0.76,3.39)	0.218
SIRI	1.48(0.90,2.45)	0.123	1.10(0.70,1.72)	0.681	1.55(0.73,3.28)	0.225

¹The model 1 was not adjusted for any covariates
²Model 2 was adjusted for age, gender, and race
³Model 3 was adjusted for all covariates based on model 1
Bold values indicate statistical significance at P<0.05. MASLD, metabolic dysfunction-associated steatotic liver disease; ALF, advanced liver fibrosis; NPR, neutrophil to platelet ratio; NHR, neutrophil to HDL-C cholesterol ratio; SII, systemic immune-inflammation index; SIRI, systemic inflammatory response index

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